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The Zhu Lab
Neuroscience & Neuroengineering
The neuroscience and neuroengineering research in our lab is centered on aging and dementia, including Alzheimer's disease. Our studies cover a broad range of topics, from risk factors and molecular and cellular mechanisms to therapeutic approaches for treating neurological disorders.
Dietary Risk Factors in AD
Can the food we eat influence the risk of developing Alzheimer's disease (AD)? Research indicates that our diet significantly impacts brain aging and function. We are exploring how dietary factors contribute to the development of aging-related diseases such as AD, and other diseases.
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Supplemental Nutrition for AD
Supplements, including supplemental elements like Magnesium, might help prevent AD or cognitive decline. The speculation is that these dietary add-ons might attack oxidative damage or inflammation, protect nerve cells, or influence other biological processes involved in AD.
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Drugs and Therapeutics for AD
So far, there are no effective drugs to treat or prevent AD. We are developing novel small molecules, therapeutic compounds, peptides, and drugs that target critical pathways involved in dementia and AD.
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Adult Neurogenesis
Stem cell therapies have emerged as promising alternatives for cognitive impairments and neuronal tissue engineering. Cerebral organoids, which are self-organizing 3D cell cultures, demonstrate improved survival rates compared to transplanted stem cells. Consequently, our group is focused on developing cerebral organoids as a novel treatment strategy for brain regeneration in cases of brain injury and neurodegenerative diseases.
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